The main aim of this study is to identify protective factors and risk factors linked to alcohol consumption in university students of both sexes. These factors were measured on the basis of a descriptive cross-sectional study developed in 2007-2008 at the University of Huelva. In order to analyze the relations among variables, we have used the chi-square test of Pearson. To identify risk and protective factors a binomial logistic regression analysis was conducted. The results confirm the influence of policonsumption and sex as the main risk factors. "Botellones" decrease predictive degree when compared with usual consumption. Reading habit, love of music and age behave as protective factors against drugs consumption. Finally, lower drinking degrees inside the college, higher frequency of attendance and lower weekly alcohol consumption, are protective factors.